Context-Specific Coordinately Regulatory Network Prioritize Breast Cancer Genetic Risk Factors
نویسندگان
چکیده
منابع مشابه
Breast Cancer: Risk Factors, Diagnosis and Management
ABSTRACT Breast cancer remains the most common cancer of women and one of the most common causes of cancer-related deaths worldwide. In spite of major advances in breast cancer diagnosis and treatment, the incidence of breast cancer remains high and the treatment of metastatic breast cancer remains challenging. This review presents an over...
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Breast cancer associated with germline pathogenic variants in BRCA1 or BRCA2 is recognized for its strong familial risk [1]. In addition to these BRCA1 and BRCA2 variants, other rare (allele frequency < 0.005) highly penetrant variants in TP53, PTEN, and ATM account for ~25% of breast cancer familial risk [2]. Other susceptibility genes have been identified (PALB2, CHEK2, RECQL, NBN) as well as...
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ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...
متن کاملGenetic polymorphism in ERCC5 and breast cancer risk
ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...
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Background: Breast cancer incidence has increased rapidly inKuwait, but there haven’t been any studies investigating the recognized risk factors of breast cancer inKuwait. The aim of the study was to investigate breast cancer risk factors among women inKuwait. Methods: A case-control study was conducted in Kuwait from May 2003 to March 2004 using a questionnaire including socio-demographic data...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2020
ISSN: 1664-8021
DOI: 10.3389/fgene.2020.00255